Adiponectin as a routine clinical biomarker

被引:141
作者
Kishida, Ken [1 ]
Funahashi, Tohru [1 ,2 ]
Shimomura, Iichiro [1 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, Suita, Osaka 5650871, Japan
关键词
visceral fat; adiponectin; hypoadiponectinemia; obesity-related diseases; VISCERAL FAT ACCUMULATION; CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE; SERUM URIC-ACID; PLASMA-PROTEIN ADIPONECTIN; MESENTERIC ADIPOSE-TISSUE; OBSTRUCTIVE SLEEP-APNEA; INDEPENDENT RISK-FACTOR; STAGE RENAL-DISEASE; ALL-CAUSE MORTALITY;
D O I
10.1016/j.beem.2013.08.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 mu g/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), sleep apnea, non-alcoholic fatty liver disease, gastritis and gastro-esophageal reflux disease, inflammatory bowel diseases, pancreatitis, osteoporosis, and cancer (endometrial cancer, postmenopausal breast cancer, leukemia, colon cancer, gastric cancer, prostate cancer). On the other hand, hyperadiponectinemia is associated with cardiac, renal and pulmonary diseases. This review article focuses on the significance of adiponectin as a clinical biomarker of obesity-related diseases. Routine measurement of adiponectin in. patients with lifestyle-related disease is highly recommended. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:119 / 130
页数:12
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