Role of Oxidative Stress in Pathogenesis of Varicocele and Infertility

被引：162

作者：

Agarwal, Ashok ^{[1
,2
,3
]}

Sharma, Rakesh K.

Desai, Nisarg R.

Prabakaran, Sushil

Tavares, Antonio

Sabanegh, Edmund

机构：

[1] Cleveland Clin, Ctr Reprod Med, Glickman Urol & Kidney Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin, Obstet Gynecol & Womens Hlth Inst, Cleveland, OH 44195 USA

[3] Lerner Coll Med, Cleveland Clin, Dept Surg, Cleveland, OH 44195 USA

来源：

UROLOGY | 2009年 / 73卷 / 03期

关键词：

OXYGEN SPECIES LEVELS; INTERNAL SPERMATIC VEIN; ANTIOXIDANT CAPACITY; NITRIC-OXIDE; ADOLESCENT VARICOCELE; SEMEN CHARACTERISTICS; SEMINAL PLASMA; TESTIS SIZE; PART II; MEN;

D O I：

10.1016/j.urology.2008.07.053

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

This review summarizes the published literature about the role of oxidative stress in the pathophysiology of varicocele and the beneficial effects of varicocele repair on oxidative stress. Literature survey was performed using the Medline, EMBASE, BIOSIS, and Cochrane databases between 1993 and 2008 that were relevant to oxidative stress and varicocele. Varicocele treatment can reduce reactive oxygen species levels and improve sperm parameters and pregnancy rates, although it is still controversial with Assisted Reproductive Techniques outcomes. We conclude that spermatozoal dysfunction in varicocele patients could be multifactorial, and oxidative stress-induced injury appears to be one of the main causes. UROLOGY 73: 461-469, 2009. (C) 2009 Elsevier Inc.

引用

收藏

页码：461 / 469

页数：9

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