Development and Validation of a New Clinical Prediction Model of Catheter-Related Thrombosis Based on Vascular Ultrasound Diagnosis in Cancer Patients

被引：19

作者：

Liu, Binliang ^{[1
]}

Xie, Junying ^{[2
]}

Sun, Xiaoying ^{[3
]}

Wang, Yanfeng ^{[4
]}

Yuan, Zhong ^{[5
]}

Liu, Xiyu ^{[6
]}

Huang, Zhou ^{[7
]}

Wang, Jiani ^{[1
]}

Mo, Hongnan ^{[1
]}

Yi, Zongbi ^{[1
]}

Guan, Xiuwen ^{[1
]}

Li, Lixi ^{[1
]}

Wang, Wenna ^{[1
]}

Li, Hong ^{[8
]}

Ma, Fei ^{[1
]}

Zeng, Yixin ^{[9
,10
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Med Oncol,Canc Hosp, Beijing, Peoples R China

[2] Canc Hosp Huanxing, Dept Management, Beijing, Peoples R China

[3] Canc Hosp Huanxing, Dept Med Oncol, Beijing, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Dept Comprehens Oncol,Canc Hosp, Beijing, Peoples R China

[5] Cent South Univ, Vasc Access Ctr, Hunan Canc Hosp, Affiliated Canc Hosp,Xiangya Sch Med, Changsha, Peoples R China

[6] Cent South Univ, Dept Lymphoma & Hematol, Hunan Canc Hosp, Affiliated Canc Hosp,Xiangya Sch Med, Changsha, Peoples R China

[7] Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Dept Radiat Oncol,Canc Hosp & Inst, Beijing, Peoples R China

[8] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China

[9] Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China

[10] Sun Yat Sen Univ, State Key Lab Oncol South China, Canc Ctr,Collaborat Innovat Ctr Canc Med, Guangzhou, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2020年 / 7卷

关键词：

catheters; thrombosis; nomogram; risk factor; cancer; CENTRAL VENOUS CATHETERS; INSERTED CENTRAL CATHETERS; DEEP-VEIN THROMBOSIS; RISK-FACTORS; COMPLICATIONS; CHEMOTHERAPY; PREVENTION; THROMBOPROPHYLAXIS; THROMBOEMBOLISM; POPULATION;

D O I：

10.3389/fcvm.2020.571227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Central venous catheters are convenient for drug delivery and improved comfort for cancer patients, but they also cause serious complications. The most common complication is catheter-related thrombosis (CRT). Objectives: This study aimed to evaluate the incidence and risk factors for CRT in cancer patients and develop an effective prediction model for CRT in cancer patients. Methods: The development of our prediction model was based on a retrospective cohort (n = 3,131) from the National Cancer Center. Our prediction model was confirmed in a prospective cohort from the National Cancer Center (n = 685) and a retrospective cohort from the Hunan Cancer Hospital (n = 61). The predictive accuracy and discriminative ability were determined by receiver operating characteristic (ROC) curves and calibration plots. Results: Multivariate analysis demonstrated that sex, cancer type, catheter type, position of the catheter tip, chemotherapy status, and antiplatelet/anticoagulation status at baseline were independent risk factors for CRT. The area under the ROC curve of our prediction model was 0.741 (CI: 0.715-0.766) in the primary cohort and 0.754 (CI: 0.704-0.803) and 0.658 (CI: 0.470-0.845) in validation cohorts 1 and 2, respectively. The model also showed good calibration and clinical impact in the primary and validation cohorts. Conclusions: Our model is a novel prediction tool for CRT risk that accurately assigns cancer patients into high- and low-risk groups. Our model will be valuable for clinicians when making decisions regarding thromboprophylaxis.

引用

页数：13

共 47 条

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