New Topics in Vasopressin Receptors and Approach to Novel Drugs: Role of the Vasopressin Receptor in Psychological and Cognitive Functions

被引：32

作者：

Egashira, Nobuaki ^{[1
,2
]}

Mishima, Kenichi ^{[1
]}

Iwasaki, Katsunori ^{[1
]}

Oishi, Ryozo ^{[2
]}

Fujiwara, Michihiro ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Fukuoka 8140180, Japan

[2] Kyushu Univ Hosp, Dept Pharm, Fukuoka 8128582, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2009年 / 109卷 / 01期

关键词：

arginine vasopressin; V1a receptor; V1b receptor; behavior; psychiatric disorder; knockout mice; MEDIAL PREFRONTAL CORTEX; 8-ARM RADIAL MAZE; CORTICOTROPIN-RELEASING HORMONE; SCOPOLAMINE-INDUCED IMPAIRMENTS; SENSORIMOTOR GATING DEFICITS; PLASMA ARGININE-VASOPRESSIN; ANXIETY-RELATED BEHAVIOR; PREPULSE INHIBITION; ANTIPSYCHOTIC-DRUGS; SCHIZOPHRENIC-PATIENTS;

D O I：

10.1254/jphs.08R14FM

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Arginine vasopressin (AVP) is a neurohypophyseal peptide best known as an antidiuretic hormone. AVP receptors have been classified into three subtypes: V1a, V1b, and V2 receptors. V1a receptor (V1aR) and V1b receptor (V1bR) are widely distributed in the central nervous system, including the septum, cortex, hippocampus, and hypothalamus. Clinical studies have demonstrated an involvement of AVP in psychiatric disorders. In the present study, we examined the performance of V1aR or V1bR knockout (KO) mice compared to wild-type (WT) mice in behavioral tests. V1aR and V1bR KO mice exhibited deficits of social behavior and prepulse inhibition in comparison to WT mice. Moreover, V1aR KO mice exhibited reduced anxiety-like behavior and impairment of spatial learning. These results suggest that V1aR and V1bR play an important role in psychological and cognitive functions.

引用

页码：44 / 49

页数：6

共 69 条

[1] Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression [J].