New triterpenoids from acorns of Quercus liaotungensis and their inhibitory activity against α-glucosidase, α-amylase and protein-tyrosine phosphatase 1B

被引：43

作者：

Xu, Jing ^{[1
]}

Cao, Jiaqing ^{[1
,2
]}

Yue, Jiayin ^{[1
]}

Zhang, Xiaoshu ^{[1
,2
]}

Zhao, Yuqing ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 41卷

关键词：

Acorn; Quercus liaotungensis; Triterpenoids; Hypoglycaemic; alpha-Glucosidase and PTP1B inhibitory activities; CONSTITUENTS; CHINENSIS;

D O I：

10.1016/j.jff.2017.12.054

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Acorn has been used as a functional food with numerous nutritional and active ingredients. In this study, 3 new triterpenoids, together with 22 known compounds were isolated from acorns (Quercus liaotungensis) and further confirmed by NMR. In order to disclose the hypoglycaemic ingredients, the extracts and all the discovered compounds were researched for enzyme inhibition using in-vitro assays on alpha-amylase, alpha-glucosidase, and protein tyrosine phosphatase 1B (PTP1B). The results suggested that 75% EtOH, PE, EtOAc, and n-BuOH extracts of acorns all exhibited potent inhibitory activities against PTP1B and alpha-glucosidase. Most of the compounds showed strong inhibitory effects on PTP1B and alpha-glucosidase, especially new compounds and compound 12, their IC50 values were about 6-fold to 20-fold lower than positive control, all showed competitive inhibitory pattern. The result suggested that triterpenoids from acorns are potential functional food ingredients that can be used as new anti-diabetic agent.

引用

页码：232 / 239

页数：8

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