Fractionating the anterior temporal lobe: MVPA reveals differential responses to input and conceptual modality

被引:38
作者
Murphy, Charlotte [1 ]
Rueschemeyer, Shirley-Ann
Watson, David
Karapanagiotidis, Theodoros
Smallwood, Jonathan
Jefferies, Elizabeth
机构
[1] Univ York, Dept Psychol, York YO10 5DD, N Yorkshire, England
基金
英国生物技术与生命科学研究理事会; 欧洲研究理事会;
关键词
Anterior temporal lobe (ATL); Multi voxel pattern analysis (MVPA); Semantic; Hub; Spoke; Resting-state connectivity; REPRESENTATIONAL SIMILARITY ANALYSIS; DISTORTION-CORRECTED FMRI; SEMANTIC MEMORY; DEFAULT-MODE; OBJECT REPRESENTATIONS; BRAIN MECHANISMS; INFORMATION; LANGUAGE; CONNECTIVITY; WORDS;
D O I
10.1016/j.neuroimage.2016.11.067
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Words activate cortical regions in accordance with their modality of presentation (i.e., written vs. spoken), yet there is a long-standing debate about whether patterns of activity in any specific brain region capture modality invariant conceptual information. Deficits in patients with semantic dementia highlight the anterior temporal lobe (ATL) as an amodal store of semantic knowledge but these studies do not permit precise localisation of this function. The current investigation used multiple imaging methods in healthy participants to examine functional dissociations within ATL. Multi-voxel pattern analysis identified spatially segregated regions: a response to input modality in anterior superior temporal gyrus (aSTG) and a response to meaning in more ventral anterior temporal lobe (vATL). This functional dissociation was supported by resting-state connectivity that found greater coupling for aSTG with primary auditory cortex and vATL with the default mode network. A meta-analytic decoding of these connectivity patterns implicated aSTG in processes closely tied to auditory processing (such as phonology and language) and vATL in meaning-based tasks (such as comprehension or social cognition). Thus we provide converging evidence for the segregation of meaning and input modality in the ATL.
引用
收藏
页码:19 / 31
页数:13
相关论文
共 77 条
[1]   The default network and self-generated thought: component processes, dynamic control, and clinical relevance [J].
Andrews-Hanna, Jessica R. ;
Smallwood, Jonathan ;
Spreng, R. Nathan .
YEAR IN COGNITIVE NEUROSCIENCE, 2014, 1316 :29-52
[2]  
[Anonymous], CEREBRAL CORTEX
[3]  
[Anonymous], CEREB CORTEX
[4]  
[Anonymous], TRACT TERMINATIONS T
[5]  
[Anonymous], J COGN NEUROSCI
[6]  
[Anonymous], 2013, COGNITIVE NEUROSCIEN
[7]  
[Anonymous], NEUROIMAGE
[8]  
[Anonymous], CORTEX
[9]  
[Anonymous], 2015, ANN REV NEUROSCI
[10]   Brain networks underlying bistable perception [J].
Baker, Daniel H. ;
Karapanagiotidis, Theodoros ;
Coggan, David D. ;
Wailes-Newson, Kirstie ;
Smallwood, Jonathan .
NEUROIMAGE, 2015, 119 :229-234