New insights into the autoantibody-mediated mechanisms of autoimmune bullous diseases and urticaria

被引:0
作者
Blank, M
Gisondi, P
Mimouni, D
Peserico, A
Piaserico, S
Shoenfeld, Y
Reunala, T
Zambruno, G
Di Zenzo, G
Girolomoni, G
机构
[1] Univ Verona, Dermatol Sect, Dept Biomed & Surg Sci, I-37126 Verona, Italy
[2] Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel
[3] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, IL-52621 Tel Hashomer, Israel
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[5] Rabin Med Ctr, Dept Dermatol, Petah Tiqwa, Israel
[6] Univ Padua, Dept Dermatol, Padua, Italy
[7] Tel Aviv Univ, Laura Schwarz Kipp Chair Autoimmun, IL-69978 Tel Aviv, Israel
[8] Tampere Univ, Dept Dermatol, FIN-33101 Tampere, Finland
[9] Tampere Univ Hosp, Tampere, Finland
[10] IRCCS, IDI, Mol Cell Biol Lab, Rome, Italy
关键词
autoimmune bullous diseases; urticaria; autoantibodies; pathophysiology; bullous pemphigoid; pemphigus vulgaris; dermatitis herpetiformis;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The skin is a common target of cellular and/or antibody mediated pathological immune responses. Pemphigoids, pemphigus vulgaris and dermatitis herpeti-formis are bullous disease clue to autoantibodies targeting specific proteins of the skin. The pemphigoid autoantigens are the BP180 and the BP230 antigens, two components of the epithelial basement membrane zone. Additional antigenic tat-gets reported in a portion of patients are laminin 5, the alpha 6 subunit of the hemidesmosomal integrin alpha 6 beta 4 and a glycoprotein termed p200. The epidermal and mucosal epithelial cells detachment (acantholysis) characteristic of pemphigus vulgaris is induced by autoantibodies directed against the desmoglein 3 and 1. The desmogleins are desmosomal cadherins, which play a major role in the cell-to-cell adhesion. Dermatitis herpetiformis is regarded as cutaneous phenotype of coeliac disease. A novel autoimmune hypothesis of coeliac disease links wheat gliadin and tissue transglutaminase (TG2) in the gut, which leads to T cell response and IgA autoantibody formation. In dermatitis herpetiformis skin the target for IgA deposition seems to be epidermal TG3. Urticaria is a complex syndrome caused by both immune and non-immune mechanisms. In a subsets of patients with chronic urticaria mast cell degranulation is induced by autoantibodies directed against the alpha-subunit of the high-affinity IgE receptor, and/or the IgE.
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页码:S20 / S25
页数:6
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