Two New Highly Oxygenated and Rearranged Limonoids from Phyllanthus cochinchinensis

被引：22
|
作者：
Zhao, Jian-Qiang [1 ,2 ]
Wang, Yan-Ming [1 ,2 ]
He, Hong-Ping [1 ]
Li, Sheng-Hong [1 ]
Li, Xiao-Nian [1 ]
Yang, Chong-Ren [1 ]
Wang, Dong [1 ]
Zhu, Hong-Tao [1 ]
Xu, Min [1 ]
Zhang, Ying-Jun [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 10期
基金：
中国科学院西部之光基金;
关键词：
APHANAMIXIS-POLYSTACHYA; WALSURA-COCHINCHINENSIS; BLOCKERS; SKELETON; EMBLICA; POTENT; ROOTS;
D O I：
10.1021/ol400875n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new 6/6/5/6-fused limonoid, phyllanthoid A (1), possessing both 19/30 and 19/29 oxygen bridges was isolated from Phyllanthus cochinchinensis (Euphorbiaceae), together with a new related limonoid, phyllanthoid B (2). Their structures were determined by spectroscopic analysis and single-crystal X-ray diffraction in the case of 1. Compound 1 displayed moderate antifeedant against the generalist plant-feeding insect Spodoptera exigua and cytotoxicity against the MCF-7 cell line.
引用
收藏
页码：2414 / 2417
页数：4
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