Obstructive Sleep Apnea Syndrome in Patients With Acute Myocardial Infarction: Timing of Onset of the Disease, Clinico-Functional and Some Other Characteristics

With the aim of elucidating special features of the course of acute myocardial infarction (MI) in patients with obstructive sleep apnea syndrome (OSA) we retrospectively studied clinico-functional parameters of 476 patients including 64 (13.3%) who had episodes of apnea during sleep. Frequency of OSA was 1.3 times greater in overweight patients, and 2.3 times greater in those with history of diabetes mellitus. Development of MIs in patients with OSA more often occurred during night or early morning (relative risk 6.00-7.41) and depended on the severity of OSA. Patients with MI and OSA had lowering of blood levels of high density lipoproteins, elevation of levels of triglycerides and high sensitive C-reactive protein. We noted the role of excessive neurohumoral activity in these processes. A conclusion was made about necessity of timely diagnosis of OSA during MI and timely correction of the revealed pathophysiological traits.