Condensed bridgehead nitrogen heterocyclic systems:: Synthesis and antimicrobial activity of thiazolo[3′,2′:2,3]-as-triazino[5,6-b]indoles and isomeric thiazolo[2′,3′:3,4]-as-triazino[5,6-b]indoles

被引：0

作者：

Mohan, J ^{[1
]}

Anupama ^{[1
]}

机构：

[1] Maharshi Dayanand Univ, Dept Chem, Rohtak 124001, Haryana, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2002年 / 41卷 / 03期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2, 3-Dihydro-6-ethyl-5H-as-triazino[5, 6-b]indole-3-thione 4 on condensation with alpha-haloketone gives 3-aroylmethylthio-6-ethyl-5H-as-triazino[5, 6-b]indolehydrobromide 5 which on PPA catalyzed cyclization furnishes 3-aryl-9-ethylthiazolo[3', 2': 2, 3]-as-triazino[5, 6-b]indole 6 and not the isomer, 1-aryl-9-ethylthiazolo[2', 3': 3, 4]-as-triazino[5, 6-b]indole 8. The unequivocal synthesis of 8 has also been accomplished. The antibacterial and antifungal activity of the compound 6 has also been evaluated.

引用

页码：628 / 630

页数：3

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