Ultrasound promoted synthesis of substituted pyrazoles and isoxazoles containing sulphone moiety

被引：51
作者：
Saleh, Tamer S. [1 ]
El-Rahman, Naglaa M. Abd [1 ]
机构：
[1] Natl Res Ctr, Dept Green Chem, Cairo 12622, Egypt
来源：
ULTRASONICS SONOCHEMISTRY | 2009年 / 16卷 / 02期
关键词：
Ultrasound; Hydrazonyl halide; Pyrazole; Isoxazole; PROSTAGLANDIN SYNTHASE; SELECTIVE INHIBITOR; MESSENGER-RNA; COX-2; POTENT; ACID;
D O I：
10.1016/j.ultsonch.2008.07.012
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
Novel pyrazoles and isoxazoles were synthesized from the reaction of the carbanions of 1-aryl-2-(phenyl-sulphonyl)-ethanone with different hydrazonyl halides and 1-aryl-2-bromo-2-hydroximinoethanone in ethanol, respectively. Reactions were carried out under silent and ultrasonic conditions. In general, it was found that ultrasound irradiations enable some reactions to occur which could not be carried out under silent condition in addition to improvement in reaction times. The products were obtained in high yields and their structures were determined by elemental analyses, spectral data and X-ray diffraction. (C) 2008 Elsevier B V All rights reserved.
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收藏
页码：237 / 242
页数：6
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