Blonanserin, an Antipsychotic and Dopamine D2/D3 Receptor Antagonist, and Ameliorated Alcohol Dependence

被引：5

作者：

Takaki, Manabu ^{[1
]}

Ujike, Hiroshi ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008530, Japan

来源：

CLINICAL NEUROPHARMACOLOGY | 2013年 / 36卷 / 02期

关键词：

blonanserin; D2/D3 receptor antagonist; D3 receptor antagonist; alcohol dependence; DOUBLE-BLIND; SCHIZOPHRENIA; EFFICACY; TOLERABILITY; SEEKING; TRIAL;

D O I：

10.1097/WNF.0b013e318280028a

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak alpha(1) receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D3 receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D3 receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.

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收藏

页码：68 / 69

页数：2

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