The role of β-catenin in chronic myeloproliferative disorders

被引：7
作者：
Jauregui, Monica P.
Sanchez, Steven R.
Ewton, April A.
Rice, Lawrence
Perkins, Sherrie L. [3 ]
Dunphy, Cherie H. [2 ]
Chang, Chung-Che [1 ,4 ]
机构：
[1] Methodist Hosp, Dept Hematopathol, Res Inst, Houston, TX 77030 USA
[2] Univ N Carolina, Chapel Hill, NC 27599 USA
[3] Univ Utah, Sch Med, Salt Lake City, UT 84132 USA
[4] Cornell Univ, Weill Med Coll, New York, NY 10021 USA
来源：
HUMAN PATHOLOGY | 2008年 / 39卷 / 10期
关键词：
beta-catenin; chronic myeloproliferative disorders; immunohistochemistry;
D O I：
10.1016/j.humpath.2008.02.007
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The goal of the current study is to evaluate the role of beta-catenin in chronic myeloproliferative disorders. Expression of beta-catenin was analyzed by immunohistochemistry in formalin-fixed decalcified bone marrow biopsy specimens from 52 chronic myeloproliferative disorder cases and 6 nonchronic myeloproliferative disorder bone marrows as controls. The frequency of moderate to strong beta-catenin staining of megakaryocytes was significantly higher in polycythemia vera cases and in essential thrombocythemia cases than in chronic myelogenous leukemia cases (polycythemia vera versus chronic myelogenous leukemia, P = .002345, Fisher exact; and essential thrombocythemia versus chronic myelogenous leukemia, P = .002288), chronic idiopathic myelofibrosis cases (polycythemia vera versus chronic idiopathic myelofibrosis, P = .006707 and essential thrombocythemia versus chronic idiopathic myelofibrosis, P = .006932) or control cases (polycythemia vera versus control, P = .010489 and essential thrombocythemia versus control, P = .0113120). The erythroid and myeloid lineages showed absent to weak beta-catenin staining in most cases. In conclusion, these results indicate that the Wnt/beta-catenin signaling pathway may have a role in megakaryocytopoiesis in polycythemia vera and essential thrombocythemia. In addition, beta-catenin may be a useful marker for differentiating polycythemia vera and essential thrombocythemia from other types of chronic myeloproliferative disorders. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：1454 / 1458
页数：5
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