Roles of heat-shock proteins in antigen presentation and cross-presentation

被引：228

作者：

Li, ZH ^{[1
]}

Menoret, A ^{[1
]}

Srivastava, P ^{[1
]}

机构：

[1] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(01)00297-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Heat-shock proteins chaperone antigenic peptides that are generated within cells. Such chaperoning is a part of the endogenous pathway of antigen presentation by MHC class I molecules. In addition, peptides that are chaperoned by heat-shock proteins, or are released by cell stress or death, are taken up by antigen-presenting cells and re-presented by their MHC molecules.

引用

页码：45 / 51

页数：7

共 61 条

[11] Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity [J].

Blachere, NE ;

Li, ZH ;

Chandawarkar, RY ;

Suto, R ;

Jaikaria, NS ;

Basu, S ;

Udono, H ;

Srivastava, PK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (08) :1315-1322

[12]

Breloer M, 1999, J IMMUNOL, V162, P3141

[13] MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum [J].

Brouwenstijn, N ;

Serwold, T ;

Shastri, N .

IMMUNITY, 2001, 15 (01) :95-104

[14]

Castelli C, 2001, CANCER RES, V61, P222

[15] Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways [J].

Castellino, F ;

Boucher, PE ;

Eichelberg, K ;

Mayhew, M ;

Rothman, JE ;

Houghton, AN ;

Germain, RN .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (11) :1957-1964

[16] The dual nature of specific immunological activity of tumor-derived gp96 preparations [J].

Chandawarkar, RY ;

Wagh, MS ;

Srivastava, PK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (09) :1437-1442

[17] Heat shock protein 70 moderately enhances peptide binding and transport by the transporter associated with antigen processing [J].

Chen, D ;

Androlewicz, MJ .

IMMUNOLOGY LETTERS, 2001, 75 (02) :143-148

[18] A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins [J].

Cho, BK ;

Palliser, D ;

Guillen, E ;

Wisniewski, J ;

Young, RA ;

Chen, JZ ;

Eisen, HN .

IMMUNITY, 2000, 12 (03) :263-272

[19] The nature of the MHC class I peptide loading complex [J].

Cresswell, P ;

Bangia, N ;

Dick, T ;

Diedrich, G .

IMMUNOLOGICAL REVIEWS, 1999, 172 :21-28

[20] Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum [J].

Fruci, D ;

Niedermann, G ;

Butler, RH ;

van Endert, PM .

IMMUNITY, 2001, 15 (03) :467-476

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