Roles of heat-shock proteins in antigen presentation and cross-presentation

被引:228
作者
Li, ZH [1 ]
Menoret, A [1 ]
Srivastava, P [1 ]
机构
[1] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA
关键词
D O I
10.1016/S0952-7915(01)00297-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Heat-shock proteins chaperone antigenic peptides that are generated within cells. Such chaperoning is a part of the endogenous pathway of antigen presentation by MHC class I molecules. In addition, peptides that are chaperoned by heat-shock proteins, or are released by cell stress or death, are taken up by antigen-presenting cells and re-presented by their MHC molecules.
引用
收藏
页码:45 / 51
页数:7
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