Occupy tissue The movement in cancer metastasis

被引:20
作者
Bradbury, Peta [1 ,2 ]
Fabry, Ben [3 ]
O'Neill, Geraldine M. [1 ,2 ]
机构
[1] Childrens Hosp Westmead, Kids Res Inst, Childrens Canc Res Unit, Sydney, NSW, Australia
[2] Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia
[3] Univ Erlangen Nurnberg, Dept Phys, D-91054 Erlangen, Germany
基金
英国医学研究理事会;
关键词
migration; invasion; metastasis; adhesion; 3D; 2D; FOCAL-ADHESION KINASE; RECONSTITUTED BASEMENT-MEMBRANE; EPITHELIAL-SPECIFIC DISRUPTION; CELL-MATRIX ADHESIONS; MAMMARY-TUMOR CELLS; BREAST-CANCER; PERICELLULAR MATRIX; COLLAGEN; MIGRATION; INVASION;
D O I
10.4161/cam.21559
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The critical role of migration and invasion in cancer metastasis warrants new therapeutic approaches targeting the machinery regulating cell migration and invasion. While 2-dimensional (2D) models have helped identify a range of adhesion molecules, cytoskeletal components and regulators that are potentially important for cell migration, the use of models that better mimic the 3-dimensional (3D) environment has yielded new insights into the physiology of cell movement. For example, studying cells in 3D models has revealed that invading cancer cells may switch between heterogeneous invasion modes and thus evade pharmacological inhibition of invasion. Here we summarize published data in which the role of cell adhesion molecules in 2D vs. 3D migration have been directly compared and discuss mechanisms that regulate migration speed and persistence in 2D and 3D. Finally we discuss limits of 3D culture models to recapitulate the in vivo situation.
引用
收藏
页码:424 / 432
页数:9
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