机构:
Univ Erlangen Nurnberg, Dept Phys, D-91054 Erlangen, GermanyChildrens Hosp Westmead, Kids Res Inst, Childrens Canc Res Unit, Sydney, NSW, Australia
Fabry, Ben
[3
]
O'Neill, Geraldine M.
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机构:
Childrens Hosp Westmead, Kids Res Inst, Childrens Canc Res Unit, Sydney, NSW, Australia
Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, AustraliaChildrens Hosp Westmead, Kids Res Inst, Childrens Canc Res Unit, Sydney, NSW, Australia
O'Neill, Geraldine M.
[1
,2
]
机构:
[1] Childrens Hosp Westmead, Kids Res Inst, Childrens Canc Res Unit, Sydney, NSW, Australia
The critical role of migration and invasion in cancer metastasis warrants new therapeutic approaches targeting the machinery regulating cell migration and invasion. While 2-dimensional (2D) models have helped identify a range of adhesion molecules, cytoskeletal components and regulators that are potentially important for cell migration, the use of models that better mimic the 3-dimensional (3D) environment has yielded new insights into the physiology of cell movement. For example, studying cells in 3D models has revealed that invading cancer cells may switch between heterogeneous invasion modes and thus evade pharmacological inhibition of invasion. Here we summarize published data in which the role of cell adhesion molecules in 2D vs. 3D migration have been directly compared and discuss mechanisms that regulate migration speed and persistence in 2D and 3D. Finally we discuss limits of 3D culture models to recapitulate the in vivo situation.
机构:
Univ Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Britto, Joanne M.
Tait, Karen J.
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机构:Univ Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Tait, Karen J.
Johnston, Leigh A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic 3010, Australia
NICTA Victorian Res Lab, Parkville, Vic 3010, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Johnston, Leigh A.
Hammond, Vicki E.
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机构:Univ Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Hammond, Vicki E.
Kalloniatis, Michael
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机构:
Univ New S Wales, Ctr Eye Hlth, Sydney, NSW 2052, Australia
Univ New S Wales, Sch Optometry & Vis Sci, Sydney, NSW 2052, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Kalloniatis, Michael
Tan, Seong-Seng
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机构:
Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
机构:
Univ Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Britto, Joanne M.
Tait, Karen J.
论文数: 0引用数: 0
h-index: 0
机构:Univ Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Tait, Karen J.
Johnston, Leigh A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic 3010, Australia
NICTA Victorian Res Lab, Parkville, Vic 3010, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Johnston, Leigh A.
Hammond, Vicki E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Hammond, Vicki E.
Kalloniatis, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ New S Wales, Ctr Eye Hlth, Sydney, NSW 2052, Australia
Univ New S Wales, Sch Optometry & Vis Sci, Sydney, NSW 2052, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia
Kalloniatis, Michael
Tan, Seong-Seng
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h-index: 0
机构:
Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, AustraliaUniv Melbourne, Brain Dev & Regenerat Div, Florey Neurosci Inst, Howard Florey Inst, Parkville, Vic 3010, Australia