Relationship Between Physical Frailty and Low-Grade Inflammation in Late-Life Depression

被引:43
作者
Arts, Matheus H. L. [1 ,2 ]
Collard, Rose M. [3 ,4 ]
Comijs, Hannie C. [5 ]
Naude, Petrus J. W. [6 ]
Risselada, Roelof [1 ]
Naarding, Paul [3 ,7 ]
Voshaar, Richard C. Oude [2 ]
机构
[1] Mental Hlth Ctr Friesland, Dept Old Age Psychiat, Leeuwarden, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands
[3] Radboud Univ Nijmegen Med Ctr, Dept Psychiat, Nijmegen, Netherlands
[4] Pro Persona, Nijmegen Mental Hlth Ctr, Nijmegen, Netherlands
[5] Vrije Univ Amsterdam Med Ctr, GGZinGeest, Dept Psychiat, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
[6] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Alzheimer Res Ctr, Groningen, Netherlands
[7] Mental Hlth Care Ctr GGNet, Dept Old Age Psychiat, Apeldoorn, Netherlands
关键词
frailty; depressive disorder; inflammation; C-reactive protein; interleukin-6; lipocalin-2; neutrophil gelatinase-associated lipocalin; GELATINASE-ASSOCIATED LIPOCALIN; OLDER PERSONS; CYTOKINES; RELIABILITY; ADULTS; HEALTH;
D O I
10.1111/jgs.13528
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
ObjectivesTo determine whether physical frailty is associated with low-grade inflammation in older adults with depression, because late-life depression is associated with physical frailty and low-grade inflammation. DesignBaseline data of a cohort study. SettingPrimary care and specialized mental health care. ParticipantsIndividuals aged 60 and older with depression according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria (N=366). MeasurementsThe physical frailty phenotype, defined as three out of five criteria (weight loss, weakness, exhaustion, slowness, low physical activity level), and three inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), and neutrophil gelatinase-associated lipocalin (NGAL)) were assessed. ResultsThe physical frailty phenotype was not associated with inflammatory markers in linear regression models adjusted for sociodemographic characteristics, lifestyle characteristics, and somatic morbidity. Of the individual criteria, handgrip strength was associated with CRP (=-0.21, P=.002) and IL-6 (=-0.25, P<.001), and gait speed was associated with NGAL (=0.15, P=.02). Principal component analysis identified two dimensions within the physical frailty phenotype: performance-based physical frailty (encompassing gait speed, handgrip strength, and low physical activity) and vitality-based physical frailty (encompassing weight loss and exhaustion). Only performance-based physical frailty was associated with higher levels of inflammatory markers (CRP: =0.14, P=.03; IL-6: =0.13, P=.06; NGAL: =0.14, P=.03). ConclusionThe physical frailty phenotype is not a unidimensional construct in individuals with depression. Only performance-based physical frailty is associated with low-grade inflammation in late-life depression, which might point to a specific depressive subtype.
引用
收藏
页码:1652 / 1657
页数:6
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