Enhancement of Acetic Acid Tolerance in Saccharomyces cerevisiae by Overexpression of the HAA1 Gene, Encoding a Transcriptional Activator

被引：91

作者：

Tanaka, Koichi ^{[1
]}

Ishii, Yukari ^{[1
]}

Ogawa, Jun ^{[2
]}

Shima, Jun ^{[1
]}

机构：

[1] Kyoto Univ, Res Div Microbial Sci, Sakyo Ku, Kyoto, Japan

[2] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto, Japan

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 22期

关键词：

BIOETHANOL PRODUCTION; LACTIC-ACID; PROTEIN; CONTAMINANTS; FERMENTATION; RESISTANCE; EXPRESSION; GROWTH;

D O I：

10.1128/AEM.02356-12

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Haa1 is a transcriptional activator required for Saccharomyces cerevisiae adaptation to weak acids. Here we show that the constitutive HAA1-overexpressing strain acquired a higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular level of acetic acid was significantly lower in HAA1-overexpressing cells than in the wild-type cells.

引用

页码：8161 / 8163

页数：3

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