Convergent glycopeptide synthesis by traceless staudinger ligation and enzymatic coupling

被引：55

作者：

Liu, L

Hong, ZY

Wong, CH

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 03期

关键词：

catalysis; convergent synthesis; glycopeptides; glycoproteins; Staudinger ligation; subtilisin;

D O I：

10.1002/cbic.200500437

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Without a trace. An approach combining traceless Staudinger ligation and protease-catalyzed N-terminal azidonation has been shown to be efficient for the convergent synthesis of glycopeptides without the cysteine limitation of native chemical ligation. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：429 / 432

页数：4

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