Functional Expression and Modulation of the L-Type Ca2+ Current in Embryonic Heart Cells

被引：1

作者：

Malan, Daniela ^{[1
]}

Fleischmann, Bernd K. ^{[1
]}

机构：

[1] Univ Bonn, Inst Physiol 1, Life & Brain Ctr, D-53105 Bonn, Germany

来源：

PEDIATRIC CARDIOLOGY | 2012年 / 33卷 / 06期

关键词：

beta-Adrenergic modulation; Embryonic cardiomyocytes; L-type Ca2+ current; Muscarinic modulation; NITRIC-OXIDE SYNTHASE; BETA-ADRENERGIC MODULATION; GREEN FLUORESCENT PROTEIN; CARDIAC-SPECIFIC GENES; STEM-CELLS; DEVELOPMENTAL-CHANGES; CALCIUM CURRENT; MEDIATED INHIBITION; MUSCLE-CELLS; MOUSE HEART;

D O I：

10.1007/s00246-012-0360-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Voltage-dependent L-type Ca2+ channels (VDCCs) are critically involved in excitation contraction coupling and regulation of the force of contraction. An important mechanism contributing to the adaptation of heart function is modulation of the L-type Ca2+ current (ICa-L) by hormones of the autonomous nervous system. The signaling pathways underlying this regulation in the adult heart are well understood. However, VDCC expression and its regulation in the embryonic heart are less understood. This report therefore provides a short overview of the current knowledge on this topic using embryonic stem cells and the mouse as model systems.

引用

页码：907 / 915

页数：9

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