The Electroencephalographic Fingerprint of Sleep Is Genetically Determined: A Twin Study

被引：191

作者：

De Gennaro, Luigi ^{[1
]}

Marzano, Cristina

Fratello, Fabiana

Moroni, Fabio

Pellicciari, Maria Concetta ^{[2
]}

Ferlazzo, Fabio

Costa, Stefania

Couyoumdjian, Alessandro

Curcio, Giuseppe ^{[4
]}

Sforza, Emilia ^{[3
]}

Malafosse, Alain

Finelli, Luca A. ^{[5
,6
]}

Pasqualetti, Patrizio ^{[7
,8
]}

Ferrara, Michele ^{[9
]}

Bertini, Mario

Rossini, Paolo Maria ^{[7
,8
,10
]}

机构：

[1] Univ Roma La Sapienza, Sect Neurosci, Dept Psychol, I-00185 Rome, Italy

[2] Hosp Fatebenefratelli, Ctr S Giovanni di Dio, Ist Ricovero & Cura Carettere Sci, Brescia, Italy

[3] Hosp Univ, Neurol Ctr, Syst Nerveux Serv, Lab Explorat Fonct, Reims, France

[4] Univ Hosp Geneva, Unit Psychiat Genet, Geneva, Switzerland

[5] Salk Inst Biol Studies, Computat Neurobiol Lab, La Jolla, CA 92037 USA

[6] Howard Hughes Med Inst, La Jolla, CA USA

[7] Hosp Fatebenefratelli, Dept Neurosci, Assoc Fatebenefratelli Ricerca, Rome, Italy

[8] Ctr San Raffaele Pisana, Inst Ricovero & Cura Carattere Sci, Rome, Italy

[9] Univ Aquila, Dept Internal Med & Publ Hlth, I-67100 Laquila, Italy

[10] Univ Campus Biomed, Neurol Clin, Rome, Italy

来源：

ANNALS OF NEUROLOGY | 2008年 / 64卷 / 04期

关键词：

D O I：

10.1002/ana.21434

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Humans have an individual profile of the electroencephalographic power spectra at the 8 to 16Hz frequency during non-rapid eye movement sleep that is stable over time and resistant to experimental perturbations. We tested the hypothesis that this electroencephalographic "fingerprint" is genetically determined, by recording 40 monozygotic and dizygotic twins during baseline and recovery sleep after prolonged wakefulness. We show a largely greater similarity within monozygotic than dizygotic pairs, resulting in a heritability estimate of 96%, not influenced by sleep need and intensity. If replicated, these results will establish the electroencephalographic profile during sleep as one of the most heritable traits of humans.

引用

页码：455 / 460

页数：6

共 21 条

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