Identification of human herpesvirus 8-specific cytotoxic T-cell responses

被引：86

作者：

Osman, M

Kubo, T

Gill, J

Neipel, F

Becker, M

Smith, G

Weiss, R

Gazzard, B

Boshoff, C ^{[1
]}

Gotch, F

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Sch Med, Dept Immunol, London SW10 9NH, England

[2] Univ Erlangen Nurnberg, Inst Klin & Mol Virol, D-91054 Erlangen, Germany

[3] Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Sch Med, Dept Genitourinary Med, London SW10 9NH, England

[4] UCL, Royal Free & Univ Coll Med Sch, Dept Oncol, London, England

[5] UCL, Royal Free & Univ Coll Med Sch, Dept Mol Pathol, London, England

[6] Univ Oxford, Dunn Sch Pathol, Oxford, England

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.73.7.6136-6140.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human herpesvirus 8 (HHV-8)(or Kaposi's sarcoma;associated herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected, This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HRV-I infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.

引用

页码：6136 / 6140

页数：5

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