Dehydrative glycosylation with cyclic phosphonium anhydrides

被引：27

作者：

Dyapa, Rajendar ^{[1
]}

Dockery, Lance T. ^{[1
]}

Walczak, Maciej A. ^{[1
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Campus Box 215, Boulder, CO 80309 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 01期

关键词：

AUTOMATED OLIGOSACCHARIDE SYNTHESIS; HENDRICKSON POP REAGENT; ANOMERIC HYDROXY SUGARS; TRIFLUOROMETHANESULFONIC ANHYDRIDE; BETA-MANNOPYRANOSIDES; STEREOSELECTIVE-SYNTHESIS; SULFOXIDE METHOD; BOND FORMATION; ACTIVATION; GLYCOSIDES;

D O I：

10.1039/c6ob01812b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic phosphonium anhydrides generated from bis-phosphine oxides and trifluoromethanesulfonic anhydride are shown as general coupling reagents in a dehydrative glycosylation reaction of C1-hemiacetals. This reaction protocol is characterized by a broad substrate scope and high yields, including reactions of O-, C-, N-, and S-based nucleophiles with furanose, pyranose, and deoxysugar donors.

引用

页码：51 / 55

页数：5

共 61 条

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