Nonsense-mediated mRNA Decay and Cancer

被引：111

作者：

Popp, Maximilian W. ^{[1
,2
]}

Maquat, Lynne E. ^{[1
,2
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA

[2] Univ Rochester, Ctr RNA Biol, 601 Elmwood Ave, Rochester, NY 14642 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2018年 / 48卷

关键词：

TUMOR-CELL SURVIVAL; REGULATORY SWITCH; IN-VIVO; INHIBITION; PATHWAY; MUTANT; BRCA1; GENE; UPF1; NMD;

D O I：

10.1016/j.gde.2017.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key tumor-suppressor mRNAs. In other cases, tumors adjust NMD activity to adapt to their microenvironment. Understanding how particular tumors exploit NMD for their benefit may augment the development of new therapeutic interventions.

引用

页码：44 / 50

页数：7

共 53 条

[1] Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? [J].

Anczukow, Olga ;

Ware, Mark D. ;

Buisson, Monique ;

Zetoune, Almoutassem B. ;

Stoppa-Lyonnet, Dominique ;

Sinilnikova, Olga A. ;

Mazoyer, Sylvie .

HUMAN MUTATION, 2008, 29 (01) :65-73

[2] The human RNA surveillance factor UPF1 is required for S phase progression and genome stability [J].

Azzalin, CM ;

Lingner, J .

CURRENT BIOLOGY, 2006, 16 (04) :433-439

[3]

Cao L, 2017, CANC LETT

[4]

Cardinali M, 1997, MOL CARCINOGEN, V18, P78, DOI 10.1002/(SICI)1098-2744(199702)18:2<78::AID-MC3>3.0.CO

[5]

2-M

[6] A UPF3-mediated regulatory switch that maintains RNA surveillance [J].

Chan, Wai-Kin ;

Bhalla, Angela D. ;

Le Hir, Herve ;

Nguyen, Lam Son ;

Huang, Lulu ;

Gecz, Jozef ;

Wilkinson, Miles F. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (07) :747-U93

[7] The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma [J].

Chang, Lei ;

Li, Cuicui ;

Guo, Tao ;

Wang, Haitao ;

Ma, Weijie ;

Yuan, Yufeng ;

Liu, Quanyan ;

Ye, Qifa ;

Liu, Zhisu .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 35

[8] Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis [J].

Degenhardt, Kurt ;

Mathew, Robin ;

Beaudoin, Brian ;

Bray, Kevin ;

Anderson, Diana ;

Chen, Guanghua ;

Mukherjee, Chandreyee ;

Shi, Yufang ;

Gelinas, Celine ;

Fan, Yongjun ;

Nelson, Deirdre A. ;

Jin, Shengkan ;

White, Eileen .

CANCER CELL, 2006, 10 (01) :51-64

[9] Truncated WT1 mutants alter the subnuclear localization of the wild-type protein [J].

Englert, C ;

Vidal, M ;

Maheswaran, S ;

Ge, YM ;

Ezzell, RM ;

Isselbacher, KJ ;

Haber, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (26) :11960-11964

[10] Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1 [J].

Fan, SJ ;

Yuan, RQ ;

Ma, YX ;

Meng, QH ;

Goldberg, ID ;

Rosen, EM .

ONCOGENE, 2001, 20 (57) :8215-8235

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