Moderate Changes in CO2 Modulate the Firing of Neurons in the VTA and Substantia Nigra

被引：4
作者：
Hill, Emily [1 ]
Dale, Nicholas [1 ]
Wall, Mark J. [1 ]
机构：
[1] Univ Warwick, Sch Life Sci, Gibbet Hill, Coventry CV4 7AL, W Midlands, England
来源：
ISCIENCE | 2020年 / 23卷 / 07期
基金：
英国生物技术与生命科学研究理事会;
关键词：
VENTRAL TEGMENTAL AREA; DOPAMINERGIC-NEURONS; CHANNELS CONTRIBUTE; PH; SENSITIVITY; BRAIN; MECHANISMS; EXPRESSION; RELEASE; AROUSAL;
D O I：
10.1016/j.isci.2020.101343
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The substantia nigra (SN) and ventral tegmental area (VTA) are vital for the control of movement, goal-directed behavior, and encoding reward. Here we show that the firing of specific neuronal subtypes in these nuclei can be modulated by physiological changes in the partial pressure of carbon dioxide (PCO2). The resting conductance of substantia nigra dopaminergic neurons in young animals (postnatal days 7-10) and GABAergic neurons in the VTA is modulated by changes in the level of CO2. We provide several lines of evidence that this CO2-sensitive conductance results from connexin 26 (Cx26) hemichannel expression. Since the levels of PCO2 in the blood will vary depending on physiological activity and pathology, this suggests that changes in PCO2 couldpotentiallymodulatemotor activity, rewardbehavior, andwakefulness.
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页数：22
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