Expression of the prothymosin-α gene as a prognostic factor in lung cancer

被引：45
|
作者：
Sasaki, H
Nonaka, M
Fujii, Y
Yamakawa, Y
Fukai, I
Kiriyama, M
Sasaki, M
机构：
[1] Nagoya City Univ, Sch Med, Dept Surg 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan
[2] Nagoya City Univ, Sch Med, Dept Biochem 2, Mizuho Ku, Nagoya, Aichi 4678601, Japan
来源：
SURGERY TODAY | 2001年 / 31卷 / 10期
关键词：
prothymosin-alpha; lung cancer; prognosis;
D O I：
10.1007/s005950170040
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Prothymosin-alpha (PT alpha) is known to play a role in cell proliferation, and the PT alpha mRNA level may reflect the degree of proliferation of tumor cells. It has been reported that PT alpha mRNA levels are higher in human colon and liver cancer tissues than in the adjacent normal tissues. We examined the mRNA levels of PT alpha and c-myc in 20 lung cancers, using Bas 250OMac systems. The PT alpha and c-myc mRNA levels in lung cancer tissues were higher than those in normal lung tissues; however, the PT alpha mRNA levels did not correlate with the stage or pathological subtype of the lung cancer and there was no correlation between the expression of PT alpha and c-myc. PT alpha mRNA overexpression in lung cancer was correlated with a poor prognosis.
引用
收藏
页码：936 / 938
页数：3
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