Alleviation of bone markers in rats induced nano-zinc oxide by qurecetin and α-lipolic acid

被引：11

作者：

Abdelkarem, Hala M. ^{[1
]}

Fadda, Laila M. ^{[2
]}

Kaml, Omyma R. ^{[3
]}

机构：

[1] Natl Res Ctr, Nutr Dept, Cairo, Egypt

[2] King Saud Univ, Pharmaceut Dept, Fac Pharm, Riyadh, Saudi Arabia

[3] Natl Org Drug Control & Res NODCAR, Biochem Dept, Giza, Egypt

来源：

TOXICOLOGY MECHANISMS AND METHODS | 2016年 / 26卷 / 09期

关键词：

n-ZnO; bone turnover; qurecetin and alpha-lipolic acid and pro-inflammatory; C-REACTIVE PROTEIN; NF-KAPPA-B; LIPOIC ACID; OXIDATIVE STRESS; INTERLEUKIN-6; PRODUCTION; INFLAMMATORY CYTOKINES; DNA-DAMAGE; VITAMIN-E; IN-VIVO; QUERCETIN;

D O I：

10.1080/15376516.2016.1236424

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The purpose of this study was to evaluate the potential protective effect of qurecetin (Qur) and alpha-lipolic acid (ALA) to modulate the perturbation of bone turnover which is induced by nano-zinc oxide (n-ZnO). Rats were fasted overnight and randomly divided into two groups: G1, normal healthy animals and the other rats were administered zinc oxide nanoparticles orally by guava in a dose of 600mg/kg body weight/d for 5 sequential days in Wistar albino male rats. N-ZnO-exposed animals were randomly sub-divided into three groups: G2, n-ZnO-exposed animals; G3, n-ZnO-exposed animals co-treated with Qur (200mg/kg daily); and G4, n-ZnO-exposed animals co-treated with ALA (200mg/kg). Qur and ALA were administered orally by guava daily for three sequential weeks from the beginning of the experiment. The results revealed a significant reduction of nitiric oxide (NO) and serum level and comet assay in n-ZnO exposure rats after treatment of Qur and ALA. It was found the alteration of pro-inflammatory markers (tumor necrosis factor alpha; TNF-alpha, interleukin-6; IL-6 and C-reactive protein; CRP), bone alkaline phosphatase (B-ALP, bone formation marker), and C-terminal peptide type I collagen (CTx, bone resorption marker) levels compared with the normal group. Co-administration of Qur and ALA in nZnO- exposed rats significantly alleviated the mentioned alterations of biochemical parameters. These results suggest that Qur and ALA as antioxidant agents may be a candidate for preventive and treatment applications of impaired bone markers induced bone loss caused by nano-particles of metal oxide.

引用

页码：692 / 699

页数：8

共 77 条

[71] Liposome formulation of co-encapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model [J].