Does Autophagy Mediate Cardiac Myocyte Death During Stress?

被引：40

作者：

Nah, Jihoon ^{[1
]}

Fernandez, Alvaro F. ^{[2
]}

Kitsis, Richard N. ^{[4
,5
]}

Levine, Beth ^{[2
,3
]}

Sadoshima, Junichi ^{[1
]}

机构：

[1] Rutgers New Jersey Med Sch, Dept Cell Biol & Mol Med, 185 S Orange Ave,MSB G-609, Newark, NJ 07103 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Ctr Autophagy Res, Dallas, TX USA

[3] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX USA

[4] Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Dept Med Cardiol, Bronx, NY 10467 USA

[5] Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Dept Cell Biol, Bronx, NY 10467 USA

来源：

CIRCULATION RESEARCH | 2016年 / 119卷 / 08期

关键词：

autophagy; cardiomyopathies; heart; mitochondrial degradation; myocytes; cardiac; CELL-DEATH; HEMODYNAMIC STRESS; DEGRADATION; ISCHEMIA; INJURY;

D O I：

10.1161/CIRCRESAHA.116.309765

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although autophagy generally promotes survival of cardiac myocytes, it can also promote cardiac myocyte death under some conditions. Here, we describe how activation of autophagy leads to death of cardiac myocytes, introduce autosis as a novel and unique form of cell death by autophagy, and discuss the functional significance of autophagic cell death in cardiac myocytes.

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收藏

页码：893 / 895

页数：3

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