Bioactive thiazole and benzothiazole derivatives

被引：321
作者：
Rouf, Abdul [1 ]
Tanyeli, Cihangir [1 ]
机构：
[1] Middle E Tech Univ, Dept Chem, TR-06800 Ankara, Turkey
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 97卷
关键词：
Thiazoles; Benzothiazoles; Heterocycles; Anticancer activity; Antibacterial activity; BITHIAZOLE-TYPE ANTIBIOTICS; PHYSICOCHEMICAL PROPERTIES; STRUCTURE ELUCIDATION; MARINE SPONGE; NSC; 376128; IN-VITRO; POTENT; INHIBITORS; PEPTIDES; AGENTS;
D O I：
10.1016/j.ejmech.2014.10.058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The heterocycles are the versatile compounds existing in almost all natural products and synthetic organic compounds, usually associated with one or the other biological activity. Among the heterocycles the thiazoles and benzothiazoles occupy a prominent position. They possess a broad range of biological activities and are found in many potent biologically active molecules and drugs such as vitamin thiamine, sulfathiazol (antimicrobial drug), ritonavir (antiretroviral drug), abafungin (antifungal drug) and tiazofurin (antineoplastic drug). The thiazole moiety is abundantly found in natural products while benzothiazole moiety is rare. In this review we disclose the literature reports of thiazoles and benzothiazoles possessing different biological activities. (C) 2014 Elsevier Masson SAS. All rights reserved.
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页码：911 / 927
页数：17
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