Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

被引：81
作者：
de Steenwinkel, Jurriaan E. M. [1 ]
ten Kate, Marian T.
de Knegt, Gerjo J.
Kremer, Kristin [2 ,3 ,4 ]
Aarnoutse, Rob E. [5 ]
Boeree, Martin J. [5 ]
Verbrugh, Henri A.
van Soolingen, Dick [2 ,3 ,5 ]
Bakker-Woudenberg, Irma A. J. M.
机构：
[1] Erasmus Univ, Dept Med Microbiol & Infect Dis, Med Ctr, NL-3000 CA Rotterdam, Netherlands
[2] Natl Inst Publ Hlth, Bilthoven, Netherlands
[3] Environm Ctr Infect Dis Control RIVM, Bilthoven, Netherlands
[4] WHO, Reg Off Europe, DK-2100 Copenhagen, Denmark
[5] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands
来源：
EMERGING INFECTIOUS DISEASES | 2012年 / 18卷 / 04期
关键词：
ANTITUBERCULOSIS DRUGS; EMERGENCE; RESISTANCE;
D O I：
10.3201/eid1804.110912
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.
引用
收藏
页码：660 / 663
页数：4
相关论文
共 15 条
[1]  
Anh DD, 2000, EMERG INFECT DIS, V6, P302
[2]  
[Anonymous], 2010, Multidrug and extensively drug-resistant TB(M/XDR-TB): 2010 Global Report on Surveillance and Response
[3]  
Buu TN, 2009, INT J TUBERC LUNG D, V13, P900
[4]   Mycobacterium tuberculosis Genotype and Case Notification Rates, Rural Vietnam, 2003-2006 [J].
Buu, Tran N. ;
Huyen, Mai N. T. ;
Lan, Nguyen N. T. ;
Quy, Hoang T. ;
Hen, Nguyen V. ;
Zignol, Mafteo ;
Borgdorff, Martien W. ;
van Soolingen, Dick ;
Cobelens, Frank G. J. .
EMERGING INFECTIOUS DISEASES, 2009, 15 (10) :1570-1577
[5]   Recent and Rapid Emergence of W-Beijing Strains of Mycobacterium tuberculosis in Cape Town, South Africa [J].
Cowley, Donna ;
Govender, Dhirendra ;
February, Bradley ;
Wolfe, Mary ;
Steyn, Lafras ;
Evans, Joanna ;
Wilkinson, Robert J. ;
Nicol, Mark P. .
CLINICAL INFECTIOUS DISEASES, 2008, 47 (10) :1252-1259
[6]   Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis [J].
de Steenwinkel, Jurriaan E. M. ;
de Knegt, Gerjo J. ;
ten Kate, Marian T. ;
van Belkum, Alex ;
Verbrugh, Henri A. ;
Kremer, Kristin ;
van Soolingen, Dick ;
Bakker-Woudenberg, Irma A. J. M. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (12) :2582-2589
[7]   Beijing/W genotype Mycobacterium tuberculosis and drug resistance [J].
Glynn, JR ;
Kremer, K ;
Borgdorff, MW ;
Rodriguez, MP ;
van Soolingen, D .
EMERGING INFECTIOUS DISEASES, 2006, 12 (05) :736-743
[8]   New Susceptibility Breakpoints for First-Line Antituberculosis Drugs Based on Antimicrobial Pharmacokinetic/Pharmacodynamic Science and Population Pharmacokinetic Variability [J].
Gumbo, Tawanda .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (04) :1484-1491
[9]   High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography [J].
Hershberg, Ruth ;
Lipatov, Mikhail ;
Small, Peter M. ;
Sheffer, Hadar ;
Niemann, Stefan ;
Homolka, Susanne ;
Roach, Jared C. ;
Kremer, Kristin ;
Petrov, Dmitri A. ;
Feldman, Marcus W. ;
Gagneux, Sebastien .
PLOS BIOLOGY, 2008, 6 (12) :2658-2671
[10]   Mycobacterium tuberculosis Beijing genotype and risk for treatment failure and relapse, Vietnam [J].
Lan, NTN ;
Lien, HTK ;
Tung, LB ;
Borgdorff, MW ;
Kremer, K ;
van Soolingen, D .
EMERGING INFECTIOUS DISEASES, 2003, 9 (12) :1633-1635
12