Synthetic Strategies toward SGLT2 Inhibitors

被引：66
作者：
Aguillon, Anderson R. [1 ]
Mascarello, Alessandra [2 ]
Segretti, Natanael D. [2 ]
de Azevedo, Hatylas F. Z. [2 ]
Guimaraes, Cristiano R. W. [2 ]
Miranda, Leandro S. M. [1 ]
de Souza, Rodrigo O. M. A. [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Biocatalysis & Organ Synth Grp, BR-22941909 Rio De Janeiro, RJ, Brazil
[2] Ache Labs Farmaceut, BR-07034904 Guarulhos, SP, Brazil
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2018年 / 22卷 / 04期
关键词：
PRACTICAL STEREOSELECTIVE-SYNTHESIS; COTRANSPORTER; 2; INHIBITORS; CROSS-COUPLING APPROACH; SELECTIVE C-ARYLATION; DIABETES-MELLITUS; 1,2-ANHYDRO SUGARS; SCALABLE SYNTHESIS; GLUCOSE-TRANSPORT; DISCOVERY; TOFOGLIFLOZIN;
D O I：
10.1021/acs.oprd.8b00017
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Gliflozins are an important class of prescription drugs used to treat type II diabetes. They reduce blood sugar levels by targeting the sodium-glucose transport protein 2 (SGLT2) and consequently inhibit glucose reabsorption in the kidney. There are currently several FDA-approved gliflozins as well as others in the pipeline to be launched in the next few years. This review describes the synthetic strategies used for manufacturing SGLT2 inhibitors on both bench and industrial scales. Moreover, the drawbacks to the strategies and the improvements made to obtain selected gliflozins and their glucose derivatives over the years are highlighted.
引用
收藏
页码：467 / 488
页数：22
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