Innate immune cells in transplantation

被引：37

作者：

Spahn, Jessica H. ^{[1
]}

Li, Wenjun ^{[1
]}

Kreisel, Daniel ^{[1
,2
]}

机构：

[1] Washington Univ, Dept Surg, St Louis, MO 63110 USA

[2] Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN ORGAN TRANSPLANTATION | 2014年 / 19卷 / 01期

关键词：

innate cells; rejection; tolerance; transplantation; CLASS-I MOLECULE; ALLOGRAFT-REJECTION; NK CELLS; MESENCHYMAL TRANSITION; MEDIATED REJECTION; DENDRITIC CELLS; P-SELECTIN; MACROPHAGES; EXPRESSION; TOLERANCE;

D O I：

10.1097/MOT.0000000000000041

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Purpose of reviewTo examine the recent literature on the role of innate cells in immunity to transplanted tissue. It specifically addresses the impact of monocytes/macrophages, neutrophils, natural killer cells, and platelets.Recent findingsCurrent research indicates that innate immunity plays a dual role in response to transplanted tissue with the ability to either facilitate rejection or promote tolerance. Intriguingly, some of these cells are even capable of reacting to allogeneic cells, a feature usually only attributed to cells of the adaptive immune system.SummaryThis review highlights the new therapeutic targets in the innate immune system that may be useful in the treatment of transplant recipients. It also emphasizes the need to use caution in exploring these new therapeutics.

引用

页码：14 / 19

页数：6

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