The secondary metabolites of aff Samadera SAC-2825: An Australian Simaroubaceae with unusual chemistry

The phytochemical analysis of two collections of a new species (SAC-2825), tentatively assigned as aff. Samadera bidwillii (Simaroubaceae), has yielded a limonoid (limonin), a quassinoid (2'-acetoxy-glaucarubin), three alkaloids [2-(10'xi-acetoxyundecanyl)-1-acetoxymethyl-4-quinolone, 1-methoxy-10-methyl-acridan-9-one and 1,8-dihydroxyacridan-9-one] and seven bicycle-octane type lignans [(-)-sesamin, (-)-episesamin, fargesin, neofargesin, (-)-kobusin, (-)-epieudesmin and (-)-eudesmin]. The 4-quinolone alkaloid appears to be novel. The metabolites identified are collectively typical of the Rutales, but have a biosynthetic range never previously found together in a single species. Particularly noteworthy is the cooccurrence of limonoids and quassinoids in the same plant, which is currently unique to SAG-2825. Copyright (C) 1997 Elsevier Science Ltd.