Imidazoles as Potential Antifungal Agents: A Review

被引：113

作者：

Rani, Nidhi ^{[1
]}

Sharma, Ajay ^{[1
]}

Gupta, Girish Kumar ^{[2
]}

Singh, Randhir ^{[3
]}

机构：

[1] Himalayan Inst Pharm, Kala Amb 173030, Himachal Prades, India

[2] Maharishi Markandeshwar Univ, Maharishi Markandeshwar Coll Pharm, Dept Pharmaceut Chem, Mullana 133203, Haryana, India

[3] Maharishi Markandeshwar Univ, Maharishi Markandeshwar Coll Pharm, Dept Pharmacol, Mullana 133203, Haryana, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 11期

关键词：

Antifungal agent; Antimycotic agent; Imidazole; Structure-Activity Relationship study; ANTI-MYCOTIC IMIDAZOLES; ANTIMICROBIAL ACTIVITY; IN-VITRO; CANDIDA-ALBICANS; BIOLOGICAL-ACTIVITY; CHEMOTHERAPEUTIC NITROHETEROCYCLES; ANTIMYCOTIC PROPERTIES; THERAPEUTIC-EFFICACY; ANTIMYCOBACTERIAL ACTIVITY; 4-SUBSTITUTED IMIDAZOLE;

D O I：

10.2174/13895575113139990069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Imidazoles are one of the most promising and vigorously pursued areas of contemporary antifungal chemotherapy depicting broad spectrum and potent activity. They have relatively simple molecular nucleus, which is amenable to many structural modifications. These agents have several favorable properties such as excellent bioavailability, good tissue penetrability and permeability and a relatively low incidence of adverse and toxic effects. They have been found effective in the treatment of various infectious diseases. This paper is an attempt to review the therapeutic potential of imidazoles as antifungal with an updated account on their development.

引用

页码：1626 / 1655

页数：30

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