Pharmacotherapy of neurally mediated syncope

被引:61
作者
Benditt, DG [1 ]
Fahy, GJ [1 ]
Lurie, KG [1 ]
Sakaguchi, S [1 ]
Fabian, W [1 ]
Samniah, N [1 ]
机构
[1] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA
关键词
syncope; nervous system; pharmacology; Cardiovascular Drugs;
D O I
10.1161/01.CIR.100.11.1242
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A wide variety of pharmacological agents are currently used for prevention of recurrent neurally mediated syncope, especially the vasovagal faint. None, however, have unequivocally proven long-term effectiveness based on adequate randomized clinical trials. At the present time, beta-adrenergic receptor blockade, along with agents that increase central volume (eg, fludrocortisone, electrolyte-containing beverages), appear to be favored treatment options. The antiarrhythmic agent disopyramide and various serotonin reuptake blockers have also been reported to be beneficial. Finally, vasoconstrictor agents such as midodrine offer promise and remain the subject of clinical study. Ultimately, though, detailed study of the pathophysiology of these syncopal disorders and more aggressive pursuit of carefully designed placebo-controlled treatment studies are essential if pharmacological, prevention of recurrent neurally mediated syncope is to be placed on a firm foundation.
引用
收藏
页码:1242 / 1248
页数:7
相关论文
共 50 条
[41]   Significance of circulatory epinephrine levels in exercise-induced neurally mediated syncope [J].
Takase, B ;
Kastushika, S ;
Hamabe, A ;
Uehata, A ;
Isojima, K ;
Satomura, K ;
Nishioka, T ;
Ohsuzu, F ;
Kurita, A .
CLINICAL CARDIOLOGY, 2001, 24 (01) :15-20
[42]   INTRAINDIVIDUAL REPRODUCIBILITY OF TILT-TABLE TESTING FOR DIAGNOSIS OF NEURALLY-MEDIATED SYNCOPE [J].
HOHNLOSER, SH ;
KLINGENHEBEN, T ;
VANDELOO, A ;
HABLAWETZ, E ;
BARTSCH, S ;
JUST, H .
ZEITSCHRIFT FUR KARDIOLOGIE, 1993, 82 (06) :352-357
[43]   Distribution of syncopal episodes in children and adolescents with neurally mediated cardiac syncope through the day [J].
Kula, S ;
Olguntürk, R ;
Tunaoglu, FS ;
Saygili, A .
EUROPACE, 2005, 7 (06) :634-637
[44]   Neurally Mediated Syncope Prediction Based on Changes of Cardiovascular Performance Surrogates Algorithms Comparison [J].
Couceiro, R. ;
Carvalho, P. ;
Paiva, R. P. ;
Henriques, J. ;
Muehlsteff, J. ;
Eickholt, C. ;
Kelm, C. Brinkmeyer M. ;
Meyer, C. .
2014 7TH INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2014), 2014, :358-362
[45]   Neuroautonomic evaluation of patients with unexplained syncope: incidence of complex neurally mediated diagnoses in the elderly [J].
Rafanelli, Martina ;
Morrione, Alessandro ;
Landi, Annalisa ;
Ruffolo, Emilia ;
Chisciotti, Valentina M. ;
Brunetti, Maria A. ;
Marchionni, Niccolo ;
Ungar, Andrea .
CLINICAL INTERVENTIONS IN AGING, 2014, 9 :333-339
[46]   Cardioinhibitory carotid sinus hypersensitivity predicts an asystolic echanism of spontaneous neurally mediated syncope [J].
Maggi, Roberto ;
Menozzi, Carlo ;
Brignole, Michele ;
Podoleanu, Cristian ;
Lori, Matteo ;
Sutton, Richard ;
Moya, Angel ;
Giada, Franco ;
Orazi, Serafino ;
Grovale, Nicoletta .
EUROPACE, 2007, 9 (08) :563-567
[47]   Endogenous opioids and epinephrine in nitroglycerin provocation tilt test in patients with neurally mediated syncope [J].
Takase, B ;
Matsushima, Y ;
Umeda, E ;
Satomura, K ;
Katsushika, S ;
Ohsuzu, F ;
Sato, T ;
Kurita, A .
JAPANESE HEART JOURNAL, 2003, 44 (04) :493-503
[48]   Cerebrovascular and cardiovascular measurements during neurally mediated syncope induced by head-up tilt [J].
Schondorf, R ;
Benoit, J ;
Wein, T .
STROKE, 1997, 28 (08) :1564-1568
[49]   Patterns of hypocapnia on tilt in patients with fibromyalgia chronic fatigue syndrome nonspecific dizziness, and neurally mediated syncope [J].
Naschitz, Jochanan E. ;
Mussafia-Priselac, Renata ;
Kovalev, Yulia ;
Zaigraykin, Natalia ;
Slobodin, Gleb ;
Elias, Nizar ;
Rosner, Itzhak .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2006, 331 (06) :295-303
[50]   Neurally Mediated Syncope Triggered by COVID-19 Nasopharyngeal Swab Specimen Collection: A Case Report [J].
Bloom, William R. ;
Bloom, Thomas D. .
ALLERGY & RHINOLOGY, 2022, 13