Incorporating Graphene Oxide and Gold Nanoclusters: A Synergistic Catalyst with Surprisingly High Peroxidase-Like Activity Over a Broad pH Range and its Application for Cancer Cell Detection

被引：474
作者：
Tao, Yu [1 ,2 ]
Lin, Youhui [1 ,2 ]
Huang, Zhenzhen [1 ,2 ]
Ren, Jinsong [1 ,2 ]
Qu, Xiaogang [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 18期
基金：
中国国家自然科学基金;
关键词：
catalyst; enzyme mimetic; gold nanoclusters; graphene oxide; broad pH ranges; cancer cell detection; PROTEIN; NANOCOMPOSITES; NANOPARTICLES; OXIDATION; DELIVERY; HYBRIDS; ENZYME; HEMIN;
D O I：
10.1002/adma.201204419
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synergistic graphene oxide-gold nanocluster (GO-AuNC) hybrid has been constructed as an enzyme mimic that is able to show high catalytic activity over a broad pH range, especially at neutral pH. Importantly, the target-functionalized hybrid has been applied as a robust nanoprobe for selective, quantitative, and fast colorimetric detection of cancer cells. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2594 / 2599
页数：6
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