Further evidence for the involvement of cardiac β-adrenergic receptors in right ventricle hypertrophy and ascites in broiler chickens

被引:32
作者
Hassanzadeh, M
Buyse, J
Decuypere, E
机构
[1] Univ Tehran, Fac Vet Med, Dept Poultry Dis, Tehran, Iran
[2] Katholieke Univ Leuven, Lab Physiol & Immunol Domest Anim, B-3001 Heverlee, Belgium
关键词
D O I
10.1080/03079450120118676
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The present study was carried out to determine, first, the cardiac beta-adrenergic receptor characteristics of broiler chick embryos exposed to two different CO2 levels during the last stage of embryonic development, and second, the prophylactic effect of beta(1)-adrenoceptor blocker on right ventricular hypertrophy in broiler chickens. High CO2 embryos showed significantly higher haematocrit values, higher partial pressure of CO2 levels and lower partial pressure of O-2 levels than those of normal CO2 embryos. Exposure of chick embryos to high CO2 levels reduced the binding capacity of myocardial beta-adrenergic receptors compared with those embryos incubated at the normal CO2 level. Atenolol-supplemented diet numerically reduced ascites incidence in broiler chickens (7%) compared with birds fed the control diet (15%). In conclusion, these data support the important role of the beta-adrenergic receptor in the cardiovascular system for cardiac output, and secondary to pulmonary hypertension syndrome.
引用
收藏
页码:177 / 181
页数:5
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