A ratiometric fluorescent dye for the detection of glutathione in live cells and liver cancer tissue

被引：47
|
作者：
Zhai, Duanting [1 ]
Lee, Sung-Chan [2 ]
Yunb, Seong-Wook [2 ]
Chang, Young-Tae [1 ,2 ]
机构：
[1] Natl Univ Singapore, Inst Life Sci, Dept Chem & MedChem Program, Singapore 117543, Singapore
[2] ASTAR, Singapore Bioimaging Consortium SBIC, Lab Bioimaging Probe Dev, Singapore 138667, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 65期
关键词：
HUMAN HEPATOCELLULAR-CARCINOMA; SOLID-PHASE SYNTHESIS; PROBE DEVELOPMENT; BODIPY LIBRARY; IMAGING PROBE; SENSOR; THIOLS; MECHANISM; BOND;
D O I：
10.1039/c3cc43480j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel ratiometric biothiol probe Glutathione Green was developed. It allows quantitative measurement of glutathione in cell extracts and direct visualization of changes in glutathione levels in live cells. Remarkably, this is the first reported biothiol probe which can detect the carcinoma region of liver tissue based on the differences in the glutathione level.
引用
收藏
页码：7207 / 7209
页数：3
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