Synthesis, Characterization, and Drug Delivery from pH- and Thermoresponsive Poly(N-Isopropylacrylamide)/Chitosan Core/Shell Nanocomposites Made by Semicontinuous Heterophase Polymerization

被引：10

作者：

Alvarado, Abraham G. ^{[1
]}

Ortega, Andres ^{[2
]}

Perez-Carrillo, Lourdes A. ^{[2
]}

Ceja, Israel ^{[3
]}

Arellano, Martin ^{[2
]}

Guillermo Lopez, R. ^{[4
]}

Puig, Jorge E. ^{[2
]}

机构：

[1] Univ Guadalajara, Dept Ingn Mecan Elect, Boul M Garcia Barragan 1451, Guadalajara 44430, Jalisco, Mexico

[2] Univ Guadalajara, Ingn Quim, Boul M Garcia Barragan 1451, Guadalajara 44430, Jalisco, Mexico

[3] Univ Guadalajara, Fis, Boul M Garcia Barragan 1451, Guadalajara 44430, Jalisco, Mexico

[4] Ctr Invest Quim Aplicada, Av Ing E Reyna 140, Saltillo 25294, Coahuila, Mexico

来源：

JOURNAL OF NANOMATERIALS | 2017年 / 2017卷

关键词：

POLY N-ISOPROPYLACRYLAMIDE; NANOPARTICLES; METHACRYLATE); MICELLES; METHYL;

D O I：

10.1155/2017/6796412

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Temperature- and pH-responsive core/shell nanoparticles were prepared by semicontinuous heterophase polymerization of N-isopropylacrylamide (NIPA) in the presence of chitosan micelles for drug delivery purposes. Micelles of chitosan, formed in an acetic acid aqueous solution at 70 degrees C containing potassium persulfate, were fed with N-isopropylacrylamide (NIPA) at a controlled rate, to produce PNIPA/chitosan core/shell nanoparticles of about 350 nm. Then, the crosslinking agent, glutaraldehyde, was added to crosslink the nanoparticles. These nanocomposites were temperature-and pH-responsive, which make them suitable as controlled drug releasing agents. The nanoparticles exhibit thermoreversibility to heating-and-cooling cycles and show different responses depending on the releasing medium's pH. Drug delivery tests were performed, employing as a model drug, doxycycline hyclate.

引用

页数：7

共 33 条

[1] Swelling Behavior of Poly(N-isopropylacrylamide) Nanogels with Narrow Size Distribution Made by Semi-continuous Inverse Heterophase Polymerization [J].