Hepatic guanylate cyclase activity is decreased in a model of cirrhosis: A quantitative cytochemistry study

被引：14
作者：
Davies, NA
Hodges, SJ
Pitsillides, AA
Mookerjee, RP
Jalan, R
Mehdizadeh, S
机构：
[1] UCL, Inst Hepatol, Div Med, London, England
[2] Univ London Royal Vet Coll, Dept Vet Basic Sci, London, England
[3] Imperial Coll Sch Med, Dept Clin Chem, London, England
来源：
FEBS LETTERS | 2006年 / 580卷 / 08期
关键词：
guanylate cyclase; nitric oxide; cirrhosis; quantitative cytochemistry;
D O I：
10.1016/j.febslet.2006.02.080
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The production of nitric oxide (NO) in liver disease and its role in vascular control has been a subject of much interest in recent years. However, the activity of guanylate cyclase (GC), the enzyme activated by NO has received little attention with regard to liver disease. In this study we have utilised a quantitative cytochemical technique to examine the activity of GC on a per cell basis in a rat model of cirrhosis. Our results show a significant reduction in GC activity, indicating that vascular regulation is likely to be substantially affected irrespective of NO generation in this disease model. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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收藏
页码：2123 / 2128
页数：6
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