Background: Acute gonadotropin responses following depot leuprolide acetate injection are useful for monitoring therapeutic efficacy in central precocious puberty. Similar monitoring of therapy in patients treated with another widely used GnRH agonist, depot triptorelin, has not yet been reported. Objective: The objective of this study was to test the use of gonadotropin levels after therapeutic injections of depot triptorelin for evaluating efficacy of therapy. Patients and methods: Thirty-two patients (29 girls and three boys) were treated with triptorelin depot, 3.75 mg per vial, between 2006 and 2010. Treatment was initiated at 8.27 +/- 1.76 years (range, 4.6-11.6 years). Blood was drawn before and at variable times between 30 min and 2 h after injections. Clinical tests were retrospectively collected. Results: After the first injection, the 60-min mean luteinizing hormone (LH) level was 21.6.1 +/- 18.0 IU/L and the follicle-stimulating hormone (FSH) was 13.5 +/- 3.6 IU/L. After subsequent injections, for those who showed clinical suppression, the standard deviations above the mean were 3.6 IU/L for FSH and 2.1 IU/L for LH. The LH levels of two patients who did not suppress sufficiently were at these limits or higher. Conclusions: Sixty-minute postinjection depot triptorelin levels of LH can be successfully used to evaluate the efficacy of treatment with this agent. Limits for suppressed levels have been determined.
机构:
Stanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USAStanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USA
Bhatia, S
Neely, EK
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Stanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USAStanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USA
Neely, EK
Wilson, DM
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Stanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USAStanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USA
机构:
Indiana Univ, James Whitcomb Riley Hosp Children, Sect Pediat Endocrinol, Dept Pediat, Indianapolis, IN USAHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
Eugster, Erica A.
Rogol, Alan
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Indiana Univ, James Whitcomb Riley Hosp Children, Sect Pediat Endocrinol, Dept Pediat, Indianapolis, IN USA
Univ Virginia, Dept Pediat, Div Endocrinol, Charlottesville, VA USAHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
Rogol, Alan
Ghizzoni, Lucia
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Univ Parma, Dipartimento Eta Evolut, Ctr Stati Disendocrini & Dismetab, I-43100 Parma, ItalyHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
Ghizzoni, Lucia
Palmert, Mark R.
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h-index: 0
机构:
Hosp Sick Children, Div Endocrinol, Toronto, ON M5G 1X8, Canada
Univ Toronto, Dept Pediat, Toronto, ON, CanadaHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
机构:
Shaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Hirsch, Harry J.
Lahlou, Najiba
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Ctr Hosp Univ Cochin St Vincent de Paul, Hormonol & Metab Dis Unit, F-95014 Paris, FranceShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Lahlou, Najiba
Gillis, David
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机构:
Hadassah Univ Hosp, Dept Pediat, IL-91120 Jerusalem, Israel
Hadassah Univ Hosp, Pediat Endocrinol Clin, IL-91120 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Gillis, David
Strich, David
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Clalit Hlth Serv, Specialty Pediat Clin, IL-91010 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Strich, David
Rosenberg-Hagen, Binyamina
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Misgav Ladach Hosp, Plast Surg Ctr, IL-93190 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Rosenberg-Hagen, Binyamina
Chertin, Boris
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机构:
Shaare Zedek Med Ctr, Dept Urol, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Chertin, Boris
Farkas, Amicur
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机构:
Shaare Zedek Med Ctr, Dept Urol, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Farkas, Amicur
Hartman, Hadassa
论文数: 0引用数: 0
h-index: 0
机构:
Hormone Res Inst, IL-92548 Jerusalem, Israel
Ben Gurion Univ Negev, IL-92548 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Hartman, Hadassa
Spitz, Irving M.
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机构:
Hormone Res Inst, IL-92548 Jerusalem, Israel
Ben Gurion Univ Negev, IL-92548 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
机构:
Stanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USAStanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USA
Bhatia, S
Neely, EK
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机构:
Stanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USAStanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USA
Neely, EK
Wilson, DM
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h-index: 0
机构:
Stanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USAStanford Univ, Dept Pediat, Div Endocrinol & Diabet, Stanford, CA 94305 USA
机构:
Indiana Univ, James Whitcomb Riley Hosp Children, Sect Pediat Endocrinol, Dept Pediat, Indianapolis, IN USAHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
Eugster, Erica A.
Rogol, Alan
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, James Whitcomb Riley Hosp Children, Sect Pediat Endocrinol, Dept Pediat, Indianapolis, IN USA
Univ Virginia, Dept Pediat, Div Endocrinol, Charlottesville, VA USAHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
Rogol, Alan
Ghizzoni, Lucia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Parma, Dipartimento Eta Evolut, Ctr Stati Disendocrini & Dismetab, I-43100 Parma, ItalyHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
Ghizzoni, Lucia
Palmert, Mark R.
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sick Children, Div Endocrinol, Toronto, ON M5G 1X8, Canada
Univ Toronto, Dept Pediat, Toronto, ON, CanadaHop Robert Debre, Ctr Reference Malad Endocriniennes Croissance, F-75935 Paris 19, France
机构:
Shaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Hirsch, Harry J.
Lahlou, Najiba
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hosp Univ Cochin St Vincent de Paul, Hormonol & Metab Dis Unit, F-95014 Paris, FranceShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Lahlou, Najiba
Gillis, David
论文数: 0引用数: 0
h-index: 0
机构:
Hadassah Univ Hosp, Dept Pediat, IL-91120 Jerusalem, Israel
Hadassah Univ Hosp, Pediat Endocrinol Clin, IL-91120 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Gillis, David
Strich, David
论文数: 0引用数: 0
h-index: 0
机构:
Clalit Hlth Serv, Specialty Pediat Clin, IL-91010 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Strich, David
Rosenberg-Hagen, Binyamina
论文数: 0引用数: 0
h-index: 0
机构:
Misgav Ladach Hosp, Plast Surg Ctr, IL-93190 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Rosenberg-Hagen, Binyamina
Chertin, Boris
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Dept Urol, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Chertin, Boris
Farkas, Amicur
论文数: 0引用数: 0
h-index: 0
机构:
Shaare Zedek Med Ctr, Dept Urol, IL-91031 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Farkas, Amicur
Hartman, Hadassa
论文数: 0引用数: 0
h-index: 0
机构:
Hormone Res Inst, IL-92548 Jerusalem, Israel
Ben Gurion Univ Negev, IL-92548 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel
Hartman, Hadassa
Spitz, Irving M.
论文数: 0引用数: 0
h-index: 0
机构:
Hormone Res Inst, IL-92548 Jerusalem, Israel
Ben Gurion Univ Negev, IL-92548 Jerusalem, IsraelShaare Zedek Med Ctr, Dept Pediat, IL-91031 Jerusalem, Israel