A Straightforward Synthesis of 2,3,4,5-Tetrasubstituted Tetrahydrofuran Derivatives

被引：7

作者：

Aljarilla, Ana ^{[1
]}

Plumet, Joaquin ^{[1
]}

机构：

[1] Univ Complutense, Fac Quim, Dept Quim Organ, E-28040 Madrid, Spain

来源：

SYNTHESIS-STUTTGART | 2008年 / 21期

关键词：

metathesis; tetrahydrofurans; Hoveyda-Grubbs catalyst; oxabicyclic compounds;

D O I：

10.1055/s-0028-1083180

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of 2,3,4,5-tetrasubstituted tetrahydrofurans starting from furan via 7-oxabicyclo[2.2.1]hept-5-ene-2,3-diol (2,3-dihydroxy-7-oxanorbornene) derivatives is reported. The key step of these transformations was the sequence ring-opening metathesis-cross metathesis (ROM-CM) reactions of the oxabicyclic compounds in the presence of ethylene and using commercially available 2nd generation Hoveyda-Grubbs catalyst.

引用

页码：3516 / 3524

页数：9

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