A Straightforward Synthesis of 2,3,4,5-Tetrasubstituted Tetrahydrofuran Derivatives

被引：7
|
作者：
Aljarilla, Ana [1 ]
Plumet, Joaquin [1 ]
机构：
[1] Univ Complutense, Fac Quim, Dept Quim Organ, E-28040 Madrid, Spain
来源：
SYNTHESIS-STUTTGART | 2008年 / 21期
关键词：
metathesis; tetrahydrofurans; Hoveyda-Grubbs catalyst; oxabicyclic compounds;
D O I：
10.1055/s-0028-1083180
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise synthesis of 2,3,4,5-tetrasubstituted tetrahydrofurans starting from furan via 7-oxabicyclo[2.2.1]hept-5-ene-2,3-diol (2,3-dihydroxy-7-oxanorbornene) derivatives is reported. The key step of these transformations was the sequence ring-opening metathesis-cross metathesis (ROM-CM) reactions of the oxabicyclic compounds in the presence of ethylene and using commercially available 2nd generation Hoveyda-Grubbs catalyst.
引用
收藏
页码：3516 / 3524
页数：9
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