Omics and Drug Response

被引：110

作者：

Meyer, Urs A. ^{[1
]}

Zanger, Ulrich M. ^{[2
]}

Schwab, Matthias ^{[2
,3
]}

机构：

[1] Univ Basel, Div Pharmacol & Neurobiol, Biozentrum, CH-4056 Basel, Switzerland

[2] Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany

[3] Univ Tubingen Hosp, Dept Clin Pharmacol, D-72076 Tubingen, Germany

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 | 2013年 / 53卷

关键词：

genomic medicine; personalized medicine; pharmacogenetics; pharmacogenomics; biomarkers; genotype-phenotype; GENOME-WIDE ASSOCIATION; IMPLEMENTATION CONSORTIUM GUIDELINES; ACUTE LYMPHOBLASTIC-LEUKEMIA; SYSTEMS BIOLOGY APPROACH; BREAST-CANCER PATIENTS; COLORECTAL-CANCER; HYPERSENSITIVITY REACTIONS; MISSING HERITABILITY; CLINICAL DEVELOPMENT; GENETIC-VARIATION;

D O I：

10.1146/annurev-pharmtox-010510-100502

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of data and a major shift in our concepts of disease. These technologies will likely shape the future of health care. One aspect of these advances is that the data generated document the uniqueness of each human being in regard to disease risk and treatment response. These developments have reemphasized the concept of personalized medicine. Here we review the impact of omics technologies on one key aspect of personalized medicine: the individual drug response. We describe how knowledge of different omics may affect treatment decisions, namely drug choice and drug dose, and how it can be used to improve clinical outcomes.

引用

页码：475 / 502

页数：28

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