Anxiety and cognitive efficiency: Differential modulation of transient and sustained neural activity during a working memory task

被引:162
作者
Fales, C. L. [1 ]
Barch, D. M.
Burgess, G. C. [2 ]
Schaefer, A. [3 ]
Mennin, D. S. [4 ]
Gray, J. R. [4 ]
Braver, T. S.
机构
[1] Washington Univ, Dept Psychol, St Louis, MO 63130 USA
[2] Univ Colorado, Boulder, CO 80309 USA
[3] Univ Leeds, Leeds, W Yorkshire, England
[4] Yale Univ, New Haven, CT USA
关键词
D O I
10.3758/CABN.8.3.239
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
According to the processing-efficiency hypothesis (Eysenck, Derakshan, Santos, & Calvin, 2007), anxious individuals are thought to require greater activation of brain systems supporting cognitive control (e.g., dorsolateral prefrontal cortex; DLPFC) in order to maintain equivalent performance to nonanxious subjects. A recent theory of cognitive control (Braver, Gray, & Burgess, 2007) has proposed that reduced cognitive efficiency might occur as a result of changes in the temporal dynamics of DLPFC recruitment. In this study, we used a mixed blocked/event-related fMRI design to track transient and sustained activity in DLPFC while high- and low-anxious participants performed a working memory task. The task was performed after the participants viewed videos designed to induce neutral or anxiety-related moods. After the neutral video, the high-anxious participants had reduced sustained but increased transient activation in working memory areas, in comparison with low-anxious participants. The high-anxious group also showed extensive reductions in sustained activation of "default-network" areas (possible deactivation). After the negative video, the low-anxiety group shifted their activation dynamics in cognitive control regions to resemble those of the high-anxious group. These results suggest that reduced cognitive control in anxiety might be due to a transient, rather than sustained, pattern of working memory recruitment. Supplementary information for this study may be found at www.psychonomic.org/archive.
引用
收藏
页码:239 / 253
页数:15
相关论文
共 73 条
[1]  
[Anonymous], ANXIETY RES, DOI DOI 10.1080/08917778908249325
[2]   Inhibition and the right inferior frontal cortex [J].
Aron, AR ;
Robbins, TW ;
Poldrack, RA .
TRENDS IN COGNITIVE SCIENCES, 2004, 8 (04) :170-177
[3]   Frontal lobe mechanisms that resolve proactive interference [J].
Badre, D ;
Wagner, AD .
CEREBRAL CORTEX, 2005, 15 (12) :2003-2012
[4]   AN INVENTORY FOR MEASURING DEPRESSION [J].
BECK, AT ;
ERBAUGH, J ;
WARD, CH ;
MOCK, J ;
MENDELSOHN, M .
ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&
[5]   Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli [J].
Bishop, S ;
Duncan, J ;
Lawrence, AD .
NATURE NEUROSCIENCE, 2004, 7 (02) :184-188
[6]   Neurocognitive mechanisms of anxiety: an integrative account [J].
Bishop, Sonia J. .
TRENDS IN COGNITIVE SCIENCES, 2007, 11 (07) :307-316
[7]   PERCEIVED FUNCTIONS OF WORRY AMONG GENERALIZED ANXIETY DISORDER SUBJECTS - DISTRACTION FROM MORE EMOTIONALLY DISTRESSING TOPICS [J].
BORKOVEC, TD ;
ROEMER, L .
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 1995, 26 (01) :25-30
[8]   Linear systems analysis of functional magnetic resonance imaging in human V1 [J].
Boynton, GM ;
Engel, SA ;
Glover, GH ;
Heeger, DJ .
JOURNAL OF NEUROSCIENCE, 1996, 16 (13) :4207-4221
[9]   Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings [J].
Brahmbhatt, Shefali B. ;
Haut, Kristen ;
Csernansky, John G. ;
Barch, Deanna M. .
SCHIZOPHRENIA RESEARCH, 2006, 87 (1-3) :191-204
[10]  
Braver T.S., 2007, VARIATION WORKING ME, P76, DOI DOI 10.1093/ACPROF:OSO/9780195168648.003.0004