Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces

被引：21

作者：

Hinman, Samuel S. ^{[1
]}

Ruiz, Charles J. ^{[2
]}

Cao, Yu ^{[3
]}

Ma, Meghann C. ^{[2
]}

Tang, Jingjie ^{[3
]}

Laurini, Erik ^{[4
]}

Posocco, Paola ^{[4
]}

Giorgio, Suzanne ^{[3
]}

Pricl, Sabrina ^{[4
]}

Peng, Ling ^{[3
]}

Cheng, Quan ^{[1
,2
]}

机构：

[1] Univ Calif Riverside, Environm Toxicol, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

[3] Aix Marseille Univ, CNRS, Ctr Interdisciplinaire Nanosci Marseille, UMR 7325,Equipe Labellisee Ligue Canc, F-13288 Marseille, France

[4] Univ Trieste, DEA, Mol Simulat Engn MOSE Lab, I-34127 Trieste, Italy

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 01期

基金：

美国国家科学基金会;

关键词：

amphiphilic dendrimers; dendrimer/lipid hybrid membrane; self-assembly; supramolecular coassembly; surface plasmon resonance; SURFACE-PLASMON RESONANCE; SUPPORTED LIPID-MEMBRANES; SIRNA DELIVERY; BILAYER-MEMBRANES; DRUG-DELIVERY; IN-VIVO; POLYMERS; VESICLES; DESIGN; MATTER;

D O I：

10.1021/acsami.6b11556

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Self-assembly of supramolecular structures has become an attractive means to create new biologically inspired materials and interfaces. We report the first robust hybrid bilayer systems readily coassembled from amphiphilic dendrimers and a naturally occurring phospholipid. Both concentration and generation of the dendrithers have direct impacts on the biophysical properties of the coassemblies. Raising the dendrimer concentration increases the hybrid bilayer stability, while changes in the generation and the concentration of the embedded dendrimers impact the fluidity of the coassembled systems. Multivalent dendrimer amine terminals allow for nondestructive in situ derivatization, providing a convenient approach to decorate and modulate the local environment of the hybrid bilayer. The coassembly of lipid/dendrimer interfaces offers a unique platform for the creation of hybrid systems with modular and precisely controllable behavior for further applications in sensing and drug delivery.

引用

页码：1029 / 1035

页数：7

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