The aging oocyte-can mitochondrial function be improved?

被引：103
作者：
Bentov, Yaakov [1 ]
Casper, Robert F. [2 ]
机构：
[1] Univ Toronto, Toronto Ctr Adv Reprod Technol, Div Reprod Sci, Dept Obstet & Gynecol, Toronto, ON, Canada
[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
来源：
FERTILITY AND STERILITY | 2013年 / 99卷 / 01期
关键词：
Reproductive senescence; reactive oxygen species; mitochondrial dysfunction; mitochondrial nutrients; coenzyme Q10; OXIDATIVE STRESS; DNA CONTENT; MOUSE; MICE; TRANSPLANTATION; DYSFUNCTION; DISEASES; EMBRYOS; WOMEN; RATES;
D O I：
10.1016/j.fertnstert.2012.11.031
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In recent years, social and cultural trends have resulted in women delaying childbirth, thereby leading to reproductive senescence as a growing public health problem. We discuss potential etiologies for age-related female reproductive decline. We bring supportive evidence to the central role of mitochondrial dysfunction and oxygen radicals in the process of aging in general and reproductive senescence specifically. We also explore the role of coenzyme Q10 deficiency as a contributing factor and the effects of its administration. (Fertil Steril (R) 2013;99:18-22. (C) 2013 by American Society for Reproductive Medicine.)
引用
收藏
页码：18 / 22
页数：5
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