Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates

被引：15

作者：

Kamal, A ^{[1
]}

Reddy, DR ^{[1
]}

Reddy, PSMM ^{[1
]}

Rajendar ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 05期

关键词：

pyrrolobenzodiazepine; hydroxyazepane; DNA-binding ability;

D O I：

10.1016/j.bmcl.2005.11.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyrrolobenzodiazepine-azepane conjugates linked through different alkane spacers have been prepared and their DNA thermal denaturation studies have been carried out. One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 degrees C after incubation for 36 h at 37 degrees C. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1160 / 1163

页数：4

共 25 条

[1] Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates
Kamal, Ahmed
Reddy, K. Srinivasa
Khan, M. Naseer A.
Shetti, Rajesh V. C. R. N. C.
Ramaiah, M. Janaki
Pushpavalli, S. N. C. V. L.
Srinivas, Chatla
Pal-Bhadra, Manika
Chourasia, Mukesh
Sastry, G. Narahari
Juvekar, Aarti
Zingde, Surekha
Barkume, Madan
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (13) : 4747 - 4761
[2] Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4] benzothiadiazine linked pyrrolo[2,1-c] [1,4] benzodiazepine conjugates
Kamal, Ahmed
Khan, M. Naseer A.
Srikanth, Y. V. V.
Reddy, K. Srinivasa
Juvekar, Aarti
Sen, Subrata
Kurian, Nisha
Zingde, Surekha
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (16) : 7804 - 7810
[3] Synthesis, DNA Binding and Anticancer Activity of Pyridylimidazolidinone Linked Pyrrolo[2,1-c][1,4] benzodiazepine Conjugates
Kamal, Ahmed
Kumar, B. Ashwini
Suresh, Paidakula
LETTERS IN DRUG DESIGN & DISCOVERY, 2012, 9 (03) : 234 - 241
[4] Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity
Kamal, A
Ramulu, P
Srinivas, O
Ramesh, G
Kumar, PP
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (18) : 4791 - 4794
[5] Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity
Kamal, Ahmed
Kumar, P. Praveen
Sreekanth, K.
Seshadri, B. N.
Ramulu, P.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (08) : 2594 - 2598
[6] Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates
Kamal, Ahmed
Srikanth, Y. V. V.
Ramaiah, M. Janaki
Khan, M. Naseer Ahmed
Reddy, M. Kashi
Ashraf, Md.
Lavanya, A.
Pushpavalli, S. N. C. V. L.
Pal-Bhadra, Manika
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) : 571 - 578
[7] Synthesis, DNA Binding Ability and Anticancer Activity of 2-heteroaryl Substituted Benzimidazoles Linked Pyrrolo[2,1-c][1,4] benzodiazepine Conjugates
Kamal, Ahmed
Pogula, Praveen Kumar
Khan, Mohammed Naseer Ahmed
Seshadri, Bobburi Naga
Sreekanth, Kokkonda
MEDICINAL CHEMISTRY, 2013, 9 (05) : 651 - 659
[8] Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates
Kamal, A
Devaiah, V
Reddy, KL
Kumar, MS
BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (06) : 2021 - 2029
[9] Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents
Kamal, A
Srinivas, O
Ramulu, P
Ramesh, G
Kumar, PP
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (15) : 4107 - 4111
[10] Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4] benzodiazepines and their anticancer potential
Kamal, Ahmed
Rajender
Reddy, D. Rajasekhar
Reddy, M. Kashi
Balakishan, G.
Shaik, T. Basha
Chourasia, Mukesh
Sastry, G. Narahari
BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (04) : 1557 - 1572

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