Synthesis of alkyl 2-[2-oxopyridin-1(2H)-yl]acrylates by nucleophilic addition of alkyl propiolates catalysed by Ph3P

被引：13

作者：

Mohtat, Bita ^{[2
]}

Jabbar, Sepideh ^{[2
]}

Ghasemi, Abdollah ^{[2
]}

Yavari, Issa ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Tehran, Iran

[2] Islamic Azad Univ, Dept Chem, Karaj, Iran

来源：

JOURNAL OF CHEMICAL RESEARCH | 2008年 / 10期

关键词：

NH-acids; 2-hydroxypyridine; 2-hydroxyquinoline; 2-hydroxyisoquinoline; alkyl acrylates; alkyl propiolates; triphenylphosphine;

D O I：

10.3184/030823408X377771

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Hydroxypyridine undergoes a smooth reaction with alkyl propiolates in the presence of triphenylphosphine (15 mol%) to produce the corresponding alkyl 2-[2-oxopyridin-1 (2H)-yl]acrylates in good yields. When the reaction was performed by 2-hydroxyquinoline and 2-hydroxyisoquinoline similar alpha-substituted alkyl acrylates were obtained.

引用

页码：601 / 603

页数：3

共 17 条

[1] ADDITION-REACTIONS OF HETEROCYCLIC-COMPOUNDS .47. REACTIONS OF PYRIDINES WITH ACETYLENIC ESTERS IN PRESENCE OF CARBANION SOURCES [J].