Cobalt(II)-Catalyzed C-N Bond Formation: Synthesis of Aryl-Substituted Imidazo[1,2-a]pyridines

被引：14

作者：

Rasheed, Sk. ^{[1
,2
]}

Rao, Desaboini Nageswar ^{[1
,2
]}

Das, Parthasarathi ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Integrat Med, Div Med Chem, Canal Rd, Jammu 180001, India

[2] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 10期

关键词：

alkyne annulations; C-N bond; cobalt; imidazo[1,2-a]pyridines; COBALT-CATALYZED CYCLIZATION; ONE-POT SYNTHESIS; FACILE SYNTHESIS; TERMINAL ALKYNES; H AMINATION; COPPER; PALLADIUM; ANNULATION; METAL; ACTIVATION;

D O I：

10.1002/ajoc.201600326

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel protocol for cobalt(II)-catalyzed synthesis of 2-arylimidazo[1,2-a]pyridines and 3-arylimidazo[1,2-a]pyridines by direct C-N bond formation has been developed. This ligand- and base-free oxidative process is regio-selective and has good functional group tolerability. This annulation reaction probably involves a Co-II/Co-III catalytic system and uses molecular oxygen (O-2) as terminal oxidant. This cobalt catalyst system is simple and efficient, which holds potential for application in C-N bond formation.

引用

页码：1213 / 1218

页数：6

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